That’s pretty impressive. I hadn’t even thought oral treatments were possible!

It’s amazing.

CRISPR makes gene editing easier, but unless you’ve got a way to deliver it to every cell, it won’t do much unless you’re targeting such a small number of cells that it’s realistic to have a technician physically inject it into a cell.

That would work for an embryo. Ignoring the plethora of ethical issues and the lack of data on long-term effects, it would probably be pretty easy for a scientist to make the change in an embryo and then go through the normal in-vitro fertilization procedure.

For a whole organism, though, it’s more difficult. One obvious solution is a specially modified virus, and that’s under research.

There’s a lot of stuff here if you want to dive deep:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356196/#sec3-biomolecules-10-00839title

It’s speculation, but from my experience with Accutane I can infer the following possibility:

• an earwax blockage could get worse because of dry earwax depending on the particular ear

Also speculation:

• if there’s fewer lipids in sweat, you keep those fats, and potentially you lose less weight.

Well there’s a pretty easy fix unless it’s an extreme case. Razor and antiperspirant (or just deodorant if you’re worried about aluminium).

Maybe she’s used to it. Maybe it’s not that bad to her. Or maybe she just thinks it’s impolite to point it out.

Maybe you’re right and you really don’t smell much. But most cases I’ve seen actually did smell.

For a few months, while I was taking Accutane, my earwax turned dry and flaky. It was awesome. It would come out much more easily, it wouldn’t accumulate, and for once my ears stopped producing so much liquid. But I imagine depending on your unique body, it could make things quite a bit worse if you manage to get an earwax blockage.

Disclaimer: do not take Accutane for more than a few months, unless your doctor really knows what they’re doing. Apparently there are significant risks associated with long-term usage.

And pure speculation, but I imagine if you’re not excreting that fat, you might lose a tiny bit less weight when exercising?

We can do this on isolated cells, but I really don’t think we have a way to distribute such a change across the zillions of cells in a human body.

And even if we could, it’s not clear how much effect altering the gene after the fact would have. Maybe once your apocrine glands have obeyed the gene and developed a certain way, it’s too late.

That said… Sign me the hell up.

https://www.merriam-webster.com/grammar/couple-few-several-use

Couple is used to refer to two things, but is also often used for a small number greater than two.

by the 1500s, it was also being used in the phrase a couple of to refer to an indefinite but still small number of people or things

Verdict: couple is used of small numbers most of the time, but usually at least two or more.

So yeah, the meaning of “at least two but possibly a bit more than that” has been around for a loooooong time.

Aw come on, those are two very different meanings of the word in my book. As it happens, the couple of eggs I took out of the fridge aren’t in a romantic relationship.

It’s pronounced niche, not niche, damn it.

Disagree. I’ve always understood it to mean approximately two. Usually 2-3; 4 isn’t outlandish.

Unless that’s the meaning, the expression doesn’t have a reason to exist. So that’s how I decide to interpret it.

I’m gonna be representative of the idiots here and ask:

I don’t get the difference. Please help.

To be honest I just look at the state of the world and laugh like I’m watching a sad comedy.

And I avoid thinking about how I’m in it and I have basically zero power over it.

I vote for whomever is the least bad candidate and try not to think about it too much the rest of the time.

Blacklist-based ad blocking.

I don’t mind ads when they’re reasonable. If it helps fund your website at all, advertise away. But when there’s a sticky banner plus an autoplay video ad reducing my mobile viewport to a ridiculous degree, and the X buttons are too small to click and ad loading completely breaks the search bar until it’s done (hi fandom wiki) I want to be able to say “fuck these ads in particular”

I’ll preface all this by saying I’m not a native speaker of English, so my standards may be a bit lower than average.

Well the rallying support bit was a bit complicated. I also didn’t understand what HMMV meant at first.

That whole thing about a red line confused me at first. I thought you meant the geographical front line of the conflict.

Also it’s still not 100% clear to me what reaching a critical mass means in this context.

Generally speaking the sentences were a bit advanced and seemed to hedge on someone understanding military stuff and having a pretty extensive background on the conflict. I had to reread it attentively to understand, which is not what I’d generally expect of an ELI5 reply.

There’s also that whole thing about foreign weapons and their suppliers having some degree of control over what Ukrainians do with them, which wasn’t obvious to me.

Very complete answer but not very “like I’m five”

So which instance an account is from matters regarding which communities you can join? Huh.

I heard what lemmy is. I googled Lemmy. I downloaded an app. I pressed sign up. I ended up on Lemmy.world.

I’ll be honest I don’t even really understand what different instances do.