I’m currently playing Hades (a top-down, isometric brawler). The gameplay is really fun and with different weapons, skills & upgrades per run, it stays entertaining for a long time. The story is simple but engaging, and after almost every run, there are some characters with new dialogue that tells you more about it.
You’re right, Hades is not a very strategic game. There are some synergies between the power-ups, but mostly I just pick the ones that suit my playstyle. I’d also say that the power-ups in Hades are just there to mix it up a bit (and not really a core part of the gameplay loop).