There is a lot of potential in asymmetrical games in general with certain players having access to different information and strategies than others due to their perspectives… letalone adding VR to the mix. I am imagining that the VR players can pull out a clipboard or tablet containing secret info, in order to try to obtain separate objectives or even hamper the other controller based players with them having to ferret out the traitor or stop the VR faction from achieving their objectives!
Making a standard dark souls or Nioh like game, but with a co-op that incorporated Puzzle Quest like mechanics could be cool. In order to power up the main character the side kick could make certain matches in their match 3 game, or to pick locks, or cast spells, or even Estus flask use.